Non-Fucosylated Anti-Human IL6 (PF-04236921) Therapeutic Antibody (CAT#: BioBet-1105ZP) Datasheet

IL6

interleukin 6

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.

IL6; interleukin 6; HGF; HSF; BSF2; IL-6; IFNB2; interleukin-6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; interferon, beta 2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2; B-cell differentiation factor

Extracellular region or secreted

Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.

Its related pathways are Transcriptional misregulation in cancer and Folate Metabolism.

Cytokines with multiple biological functions. It is a powerful inducer of acute phase reactions. It plays an important role in the differentiation of b cells into insulin-secreting cells, and participates in the differentiation of lymphocytes and monocytes. It acts on b cells, t cells, hepatocytes, hematopoietic progenitor cells and central nervous system cells. Required to produce T(H)17 cells. Also plays the role of muscle factor. After muscle contraction, it is released into the blood, which increases the breakdown of fat and improves insulin resistance. It can induce the growth of myeloma and plasmacytoma and the differentiation of nerve cells.

N- and O-glycosylated.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

PF-04236921

Human

Human

PF-04236921 is a fully human antibody that binds to and neutralizes the IL-6 ligand. There are increased levels of the cytokine in active lupus and excess production of it by T and B cells. PF-04236921 is also being evaluated for use in Crohn's disease.

Crohn's Disease; Rheumatoid Arthritis; Systemic lupus erythematosus

Crohn's Disease; Rheumatoid Arthritis; Systemic lupus erythematosus