Book a Meeting

Non-Fucosylated Anti-Human IL17A (ANB004) Therapeutic Antibody (CAT#: BioBet-1055ZP) Datasheet

Target
IL17A
Isotype
IgG
Description
ADCC-Enhanced anti-IL17A (ANB004) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Autoimmune Diseases
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IL17A antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL17A
Full Name
interleukin 17A
Background
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Alternative Names
IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
Gene ID
3605
UniProt ID
Q9UK05
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with IL17A include Arthritis and Bronchiolitis Obliterans.
Related Pathways
Its related pathways are PEDF Induced Signaling and Immune response IL-23 signaling pathway.
Function
Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines.
Field of research
Cancer antibody; Immune System antibody
Post-translational modifications
Found both in glycosylated and nonglycosylated forms.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
ANB004
Host
Human
Species Reactivity
Human
Description
ANB004 is a novel anti-IL17 monoclonal antibody used for the treatment of autoimmune and inflammatory conditions. Recent clinical data has validated the therapeutic benefit of IL17 blockade in treatment of a number of autoimmune and inflammatory diseases, notably psoriasis, rheumatoid arthritis and uveitis.
Antibody Indication
Autoimmune Diseases

Autoimmune Diseases

Related Products

Anti-IL17A Antibody, Half-Life Extended (CAT#: AES-0622-ZP1137)
Anti-IL17A Antibody, On-Target (CAT#: AES-0622-ZP809)
Anti-IL17A Antibody, FcγRIIB Binding Enhanced (CAT#: AES-0622-ZP481)
Anti-IL17A Antibody, Recycling (CAT#: AES-0622-ZP153)
Highly Galactosylated Anti-IL17A (Vunakizumab) Antibody (CAT#: BioBet-GA-290ZP)
Non-fucosylated Anti-Human IL17A (Bimekizumab) Therapeutic Antibody (CAT#: BioBet-291ZP)
Anti-IL17A Antibody, Highly Galactosylated (CAT#: BioBet-GA-289ZP)
Anti-IL17A Antibody, Non-Fucosylated (CAT#: BioBet-289ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
  • *
USA

UK

Germany

ISO 9001 Certified - Creative Biolabs Quality Management System.