Anti-IGHE Antibody, Non-Fucosylated (BioBet-279ZP) (CAT#: BioBet-279ZP) Datasheet

IGHE

Immunoglobulin Heavy Constant Epsilon

IGHE (Immunoglobulin Heavy Constant Epsilon) is a Protein Coding gene.
Diseases associated with IGHE include Toxocariasis and Allergic Rhinitis.
Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System.
Gene Ontology (GO) annotations related to this gene include antigen binding.
An important paralog of this gene is IGHG2.

Quilizumab; 1228538-47-3; RG7449; MEMP1972A; 47H4; IGHE; Immunoglobulin heavy constant epsilon;

Plasma membrane, Extracellular region or secreted

Diseases associated with IGHE include Toxocariasis and Latex Allergy.

Its related pathways are RET signaling and GAB1 signalosome.

Immunoglobulin heavy chain immobilization region. Immunoglobulins, also called antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition stage of humoral immunity, membrane-bound immunoglobulin acts as a receptor and binds to a specific antigen to trigger the expansion of B lymphocyte clones and differentiate into plasma cells that secrete immunoglobulin. The secreted immunoglobulin mediates the fluid immune response phase, leading to the elimination of bound antigens. The antigen binding site is composed of a variable domain of a heavy chain and a variable domain of a light chain related to it. Therefore, each immunoglobulin has two antigen binding sites that have significant affinity for a specific antigen. The variable domains are assembled through a process called V-(D)-j rearrangement, followed by somatic hypermutation, which allows the affinity maturation of specific antigens after exposure to antigen and selection 发送反馈 历史记录

1.Glycosylation at Asn21, Asn49, Asn99, Asn146, Asn252, and Asn275 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1, κ

BioBet-279ZP

Humanized

Human

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IGHE.

Asthma

Asthma