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Non-Fucosylated Anti-Human IgE (47H4v5) Therapeutic Antibody (CAT#: BioBet-1727ZP) Datasheet

Target
IgE
Isotype
IgG
Description
Non-Fucosylated Anti-Human IgE (47H4v5) is a glycosylation-modified therapeutic biobetter antibody.
Indication
Asthma
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IgE antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IgE
Full Name
Immunoglobulin E
Alternative Names
IgE
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
47H4v5
Host
Humanized
Species Reactivity
Human
Description
This clone was generated using a stable CHO cell line with the FUT8 knockout gene. It was 100% non-fucosylated. In an in vitro cell-based ADCC assay, the afucosylated antibody clone showed significantly higher ADCC activity compared to its wild type version. The binding affinity of the non-fucosylated Fc variant antibody to Fc receptor is much higher than than the same antibody with fucosylated Fc. Robust and stable production of qualitative fully non-fucosylated therapeutic antibodies is achieved.
Indication
Asthma

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BetterBet™ Anti-IgE Half-Life Extended Antibody (CAT#: AES-0622-ZP1216)
Non-fucosylated Anti-Human IgE (Omalizumab) Therapeutic Antibody (CAT#: BioBet-030ZP)
Highly Galactosylated Anti-IgE (Omalizumab) Antibody (CAT#: BioBet-GA-030ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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