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Anti-Hemojuvelin Antibody, Non-Fucosylated (CAT#: BioBet-975ZP) Datasheet

Target
Hemojuvelin
Isotype
IgG
Description
Anti-Hemojuvelin Antibody, Non-Fucosylated (BioBet-975ZP) is a humanized monoclonal IgG antibody against Hemojuvelin. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Iron Metabolism
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Hemojuvelin antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
HFE2
Full Name
hemochromatosis type 2 (juvenile)
Background
The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
Alternative Names
HFE2; hemochromatosis type 2 (juvenile); JH; HJV; RGMC; HFE2A; hemojuvelin; haemojuvelin; RGM domain family member C; repulsive guidance molecule c; hemochromatosis type 2 protein
Gene ID
148738
UniProt ID
Q9UK05
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with HJV include Hemochromatosis, Type 2A and Hemochromatosis Type 2.
Related Pathways
Its related pathways are Netrin-1 signaling and Signaling by BMP.
Function
Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.
Post-translational modifications
1.Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds. Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space; regulates HJV activity in BMP signaling and thefore iron homeostasis 2.Modification sites at PhosphoSitePlus 3.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-975ZP
Host
Humanized
Species Reactivity
Human
Description
The anti-Hemojuvelin antibody are used for diseases of iron metabolism, hepcidin and hemojuvelin.
Antibody Indication
Iron Metabolism

Iron Metabolism

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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