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Non-Fucosylated Anti-Human Heat Shock 70kDa Protein 9 (C69) Therapeutic Antibody (CAT#: BioBet-1012ZP) Datasheet

Target
Heat shock 70kDa protein 9
Isotype
IgG
Description
ADCC-Enhanced anti-Heat shock 70kDa protein 9 (C69) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Heat shock 70kDa protein 9 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
HSPA9
Full Name
heat shock 70kDa protein 9 (mortalin)
Background
This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.
Alternative Names
HSPA9; heat shock 70kDa protein 9 (mortalin); CSA; MOT; MOT2; CRP40; GRP75; PBP74; GRP-75; HSPA9B; MTHSP75; HEL-S-124m; stress-70 protein, mitochondrial; mortalin-2; p66-mortalin; mortalin, perinuclear; heat shock 70kD protein 9B; peptide-binding protein 74; 75 kDa glucose-regulated protein; catecholamine-regulated protein 40; epididymis secretory sperm binding protein Li 124m
Gene ID
3313
UniProt ID
Q9UK05
Cellular Localization
Mitochondrion, Nucleus
Involvement in Disease
Diseases associated with HSPA9 include Even-Plus Syndrome and Anemia, Sideroblastic, 4.
Related Pathways
Its related pathways are Cellular response to heat stress and Tuberculosis.
Function
Chaperone proteins play an important role in the biogenesis of mitochondrial iron-sulfur clusters (ISC). Interacts with the ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU and stabilizes them. Regulate erythropoiesis by stabilizing ISC assembly. May play a role in controlling cell proliferation and cell aging (through similarity).
Post-translational modifications
1.Ubiquitination at Lys121, Lys368, and Lys646 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
C69
Host
Human
Species Reactivity
Human
Description
The antibody binding heat shock 70kDa protein 9 (HSPA9) are used as active ingredients treating for cancer.
Indication
Cancer

Cancer

Related Products

Non-Fucosylated Anti-Human Heat Shock 70kDa Protein 9 (C26) Therapeutic Antibody (CAT#: BioBet-1011ZP)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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