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Non-Fucosylated Anti-Human Glycoprotein transmembrane NMB (G49) Therapeutic Antibody (CAT#: BioBet-950ZP) Datasheet

Target
Glycoprotein transmembrane NMB
Isotype
IgG
Description
ADCC-Enhanced anti-Glycoprotein transmembrane NMB (G49 ) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Indication
Tumors
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Glycoprotein transmembrane NMB antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
GPNMB
Full Name
glycoprotein (transmembrane) nmb
Background
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.
Alternative Names
GPNMB; glycoprotein (transmembrane) nmb; NMB; HGFIN; transmembrane glycoprotein NMB; osteoactivin; glycoprotein NMB; glycoprotein nmb-like protein; transmembrane glycoprotein HGFIN
Gene ID
10457
UniProt ID
Q9UK05
Cellular Localization
Plasma membrane, Endosome
Involvement in Disease
Diseases associated with GPNMB include Amyloidosis, Primary Localized Cutaneous, 3 and Lichen Amyloidosis.
Related Pathways
Its related pathways are Signaling by PTK6 and Signaling by GPCR.
Function
Could be a melanogenic enzyme.
Post-translational modifications
1.Glycosylation at Asn93, Asn134, Asn146, Asn200, Asn249, Asn275, Asn296, Asn300, Asn306, Asn312, Asn459, and Asn467 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
G49
Host
Mouse
Species Reactivity
Human
Description
The monoclonal antibody to GPNMB plays an important role in numerous cell types, as well as in tumors.
Indication
Tumors

Tumors

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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