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Non-Fucosylated Anti-Human Ganglioside GD3 (302) Therapeutic Antibody (CAT#: BioBet-1682ZP) Datasheet

Target
Ganglioside GD3
Isotype
IgG
Description
Non-Fucosylated Anti-Human Ganglioside GD3 (302) is a glycosylation-modified therapeutic biobetter antibody.
Antibody Indication
Melanoma
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Ganglioside GD3 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
ST8SIA1
Alternative Names
mitumomab;216503-58-1;BEC-2;ST8SIA1;ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sialyltransferase 1;sialyltransferase 8 (alpha N acetylneuraminate: alpha 2, 8 sialytransferase, GD3 synthase) A, SIAT8, SIAT8A;alpha-N-acetylneuraminide alpha-2, 8-sialyltrans
Gene ID
6489
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
302
Host
Chimeric
Species Reactivity
Human
Description
This clone was generated using a stable CHO cell line with the FUT8 knockout gene. It was 100% non-fucosylated. In an in vitro cell-based ADCC assay, the afucosylated antibody clone showed significantly higher ADCC activity compared to its wild type version. The binding affinity of the non-fucosylated Fc variant antibody to Fc receptor is much higher than than the same antibody with fucosylated Fc. Robust and stable production of qualitative fully non-fucosylated therapeutic antibodies is achieved.
Antibody Indication
Melanoma

Related Products

Anti-ganglioside GD3 Antibody, Non-Fucosylated (CAT#: BioBet-447ZP)
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Non-Fucosylated Anti-Human Ganglioside GD3 (GIT) Therapeutic Antibody (CAT#: BioBet-1683ZP)
Anti-ganglioside GD3 Antibody, Half-Life Extended (CAT#: AES-0622-ZP1310)
Anti-ganglioside GD3 Antibody, Recycling (CAT#: AES-0622-ZP326)
Anti-ganglioside GD3 Antibody, On-Target (CAT#: AES-0622-ZP982)
Anti-ganglioside GD3 Antibody, Highly Galactosylated (CAT#: BioBet-GA-447ZP)

All products and services are for Research Use Only. Do Not use in humans.

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