Anti-FXa Antibody, Non-Fucosylated (BioBet-847ZP) (CAT#: BioBet-847ZP) Datasheet

F10

coagulation factor X

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.

F10; coagulation factor X; FX; FXA; factor Xa; prothrombinase; Stuart-Prower factor

Extracellular region or secreted

Diseases associated with F10 include Factor X Deficiency and Hemorrhagic Disease.

Its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Gamma carboxylation, hypusine formation and arylsulfatase activation.

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

Cell Biology and Cellular Response antibody

The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway). The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-847ZP

Mouse

Human

This is an antibody binds to Factor Xa, it can be used for preventing and treating thromboembolic disorders.

Thromboembolic Disorders

Thromboembolic Disorders