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Anti-Fatty Acid Synthase Antibody, Non-Fucosylated (CAT#: BioBet-860ZP) Datasheet

Target
Fatty Acid Synthase
Isotype
IgG
Description
Anti-Fatty Acid Synthase Antibody, Non-Fucosylated (BioBet-860ZP) is a human monoclonal IgG antibody against Fatty Acid Synthase. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Fatty Acid Synthase antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
FASN
Full Name
fatty acid synthase
Background
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
Alternative Names
FASN; fatty acid synthase; FAS; OA-519; SDR27X1; short chain dehydrogenase/reductase family 27X, member 1
Gene ID
2194
Cellular Localization
Cytoplasm
Involvement in Disease
Diseases associated with FASN include Non-Alcoholic Fatty Liver Disease and Fatty Liver Disease.
Related Pathways
Its related pathways are Fatty acid biosynthesis (KEGG) and Sterol Regulatory Element-Binding Proteins (SREBP) signalling.
Function
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.
Post-translational modifications
1.Ubiquitination at Lys41, Lys70, Lys213, Lys257, Lys298, Lys326, Lys436, Lys528, Lys631, Lys992, Lys1072, Lys1116, Lys1142, Lys1151, Lys1158, Lys1239, Lys1393, Lys1429, Lys1495, Lys1591, Lys1704, Lys1739, Lys1851, Lys1866, Lys1878, Lys1911, Lys1927, Lys2391, Lys2438, and Lys2449 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-860ZP
Host
Human
Species Reactivity
Human
Description
This is an anti-Fas monoclonal antibody having an inhibitory effect of cell proliferation as an active ingredient. The anti-Fas monoclonal antibody reacts with the Fas antigen in synovial cells of patients with rheumatoid arthritis, especially the human Fas antigen specifically and expresses apoptosis on synovial cells.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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