Background
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
Alternative Names
INHBB; inhibin, beta B; inhibin beta B chain; Inhibin, beta-2; activin beta-B chain; activin AB beta polypeptide
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with INHBB include Eclampsia and Pre-Eclampsia.
Related Pathways
Its related pathways are Signaling by GPCR and PEDF Induced Signaling.
Function
Inhibin and activin inhibit and activate follitropin, respectively. Inhibin / activin regulates many different functions according to their subunit composition, such as thalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, red blood cell differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth. Inhibin seems to have the opposite function to activin.
Post-translational modifications
1.Glycosylation at Asn93 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
Mouse IgG
Description
The antibody specific for the inhibin/activin beta-B subunit polypeptide is highly specific for the beta-B subunit, it can be used to detect or monitor a wide range of physiological conditions, including variations in the menstrual cycle, granulosa cell tumors, Down's syndrome, male infertility (e. g. sertoli cell function), ovarian reserve/menopause onset, and ovarian cancer.
Indication
Down's Syndrome; Ovarian Cancer
