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Creative Biolabs - ADCC+ Antibody

Anti-Cytokeratin 8 Antibody, Non-Fucosylated (BioBet-1158ZP) (CAT#: BioBet-1158ZP) Datasheet

Target
Cytokeratin 8
Isotype
IgG
Description
Anti-Cytokeratin 8 Antibody, Non-Fucosylated (BioBet-1158ZP) is a humanized monoclonal IgG antibody against Cytokeratin 8. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Colorectal Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Cytokeratin 8 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
KRT8
Full Name
keratin 8, type II
Background
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.
Alternative Names
KRT8; keratin 8, type II; K8; KO; CK8; CK-8; CYK8; K2C8; CARD2; keratin, type II cytoskeletal 8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8
Gene ID
3856
Cellular Localization
Nucleus
Involvement in Disease
Diseases associated with KRT8 include Liver Cirrhosis and Cryptogenic Cirrhosis.
Related Pathways
Its related pathways are Cytoskeleton remodeling Neurofilaments and Signaling mediated by p38-alpha and p38-beta.
Function
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Field of research
Cancer antibody; Signaling Transduction antibody
Post-translational modifications
Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization. O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1158ZP
Host
Humanized
Species Reactivity
Human
Description
The antibody specific to human CK8 are used for preventing and treating colorectal cancers.
Antibody Indication
Colorectal Cancer

Colorectal Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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