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Anti-CXCR3 Antibody, Non-Fucosylated (AT0010) (CAT#: BioBet-949ZP) Datasheet

Target
CXCR3
Isotype
IgG
Description
Anti-CXCR3 Antibody, Non-Fucosylated (BioBet-949ZP) is a human monoclonal IgG antibody against CXCR3. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CXCR3 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CXCR3
Full Name
Chemokine receptor CXCR3
Alternative Names
CXCR3, CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR, C-X-C motif chemokine receptor 3
Gene ID
2833
UniProt ID
Q9UK05
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with CXCR3 include Cutaneous Lupus Erythematosus and Pulmonary Sarcoidosis.
Related Pathways
Its related pathways are Signaling by GPCR and GPCRs, Other.
Function
[Isoform 1]: Receptors for C-X-C chemokines CXCL9, CXCL10 and CXCL11, and mediate the proliferation, survival and angiogenesis of human mesangial cells (HMC) through the heterotrimeric g protein signaling pathway. CCL21 binding. May promote cell chemotaxis. [Isoform 2]: Receptor of C-X-C chemokine CXCL4, and mediates the inhibitory activity of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenesis of human microvascular endothelial cells (HMVEC) through camp-mediated signaling pathways. Does not promote the chemotaxis of cells. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and helps to inhibit angiogenesis. Renal cancer cell overexpression down-regulates the expression of anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3]: Regulate the activity of CXCL11.
Post-translational modifications
Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction. N-glycosylated.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
AT0010
Host
Human
Species Reactivity
Human
Description
The antibody targeting GPCR are implicated in a wide variety of diseases such as rheumatoid arthritis and Crohn disease, as well as metabolic disease and cancer.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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