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Non-Fucosylated Anti-Human CGRP (ALD403) Therapeutic Antibody (CAT#: BioBet-706ZP) Datasheet

Target
CGRP
Isotype
IgG
Description
ADCC-Enhanced anti-CGRP (ALD403) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Indication
Migraine
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced CGRP antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CGRP
Full Name
Calcitonin gene-related peptide
Background
Calcitonin gene related peptide (CGRP) is a member of the calcitonin family of peptides, which in humans exists in two forms, α-CGRP and β-CGRP. α-CGRP is a 37-amino acid peptide and is formed from the alternative splicing of the calcitonin/CGRP gene located on chromosome 11. The less-studied β-CGRP differs in three amino acids (in humans) and is encoded in a separate gene in the same vicinity.
Alternative Names
CGRP; Calcitonin gene-related peptide;
UniProt ID
P19022
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with CALCA include Reflex Sympathetic Dystrophy and Spinal Stenosis.
Related Pathways
Its related pathways are Neuroscience and Signaling by GPCR.
Function
How CGRP induces vasodilation. It dilates a variety of blood vessels, including coronary arteries, brain and blood vessels throughout the body. Its abundance in the central nervous system also indicates that it has the effect of neurotransmitter or neurotonin. It also increases platelet cAMP.
Field of research
Cancer antibody; Cell Biology and Cellular Response antibody; Neuroscience antibody; Signaling Transduction antibody
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
ALD403
Host
Humanized
Species Reactivity
Human
Description
ALD403 is a novel monoclonal antibody targeted to calcitonin gene-related peptide, or CGRP, for migraine prevention. CGRP is a validated target that is believed to play a key role in migraine.
Indication
Migraine

Migraine

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All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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