Anti-CD47 Antibody, Non-Fucosylated (MABL-1) (CAT#: BioBet-673ZP) Datasheet

CD47

CD47 molecule

This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene.

CD47; CD47 molecule; IAP; OA3; MER6; leukocyte surface antigen CD47; CD47 glycoprotein; Rh-related antigen; integrin associated protein; integrin-associated protein; integrin-associated signal transducer; antigenic surface determinant protein OA3; antigen identified by monoclonal antibody 1D8; CD47 antigen (Rh-related antigen, integrin-associated signal transducer)

Plasma membrane

Diseases associated with CD47 include Hereditary Spherocytosis and Neonatal Meningitis.

Its related pathways are Degradation of the extracellular matrix and Cell surface interactions at the vascular wall.

By acting as the adhesion receptor of THBS1 on platelets, it plays a role in cell adhesion and plays a role in the regulation of integrins. Plays an important role in hippocampal memory formation and synaptic plasticity (through similarity). SIRPA receptor, combined with it can prevent the maturation of immature dendritic cells and inhibit the production of cytokines by mature dendritic cells. The interaction with SIRPG can mediate cell-cell adhesion, enhance superantigen-dependent T cell-mediated proliferation, and synergistically stimulate T cell activation. May play a role in membrane transport and/or integrin-dependent signal transduction. Can prevent red blood cells from disappearing prematurely. It may be related to the changes in membrane permeability caused by virus infection.

Cancer antibody; Immune System antibody

1.Glycosylation at Asn23, Asn34, Asn50, Asn73, Asn111, and Asn206 2.Modification sites at PhosphoSitePlus 3.Ubiquitination at Lys74, Lys93, Lys314, and Lys317

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

MABL-1

Humanized

Human

This is a single-chain antibody fragment (scFv) monoclonal antibody which specifically bound to human CD47 (hCD47) and induced apoptosis of the leukemic cells.

B-cell malignancies

B-cell malignancies