Non-Fucosylated Anti-Human CD19 (MDX-1342) Therapeutic Antibody (CAT#: BioBet-645ZP) Datasheet

CD19

CD19 molecule

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4

Plasma membrane

Diseases associated with CD19 include Immunodeficiency, Common Variable, 3 and Common Variable Immunodeficiency.

Its related pathways are RET signaling and B cell receptor signaling pathway (KEGG).

As a co-receptor of b cell antigen receptor complex (BCR) on b lymphocytes. Lower the threshold of downstream signal pathway activation and trigger b-cell response to antigen. Activating the signaling pathway leads to the activation of phosphatidylinositol 3-kinase and mobilization of intracellular Ca(2+) storage. Not needed in the early steps of bone marrow B cell differentiation. Necessary for normal differentiation of B-1 cells (similarity). Normal B cell differentiation and proliferation are required to respond to antigen challenges. Requires normal levels of serum immunoglobulin, and the production of high-affinity antibodies upon antigen challenge.

Developmental Biology antibody; Immune System antibody; Lymphocyte Marker antibody; B cell Marker antibody; Pro-B Cell Marker antibody; Pre-B Cell Marker antibody; Immature B Cell Marker antibody; Follicular dendritic cells antibody

Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

MDX-1342

Human

Human

MDX-1342 is a fully human monoclonal antibody (HuMAb) with enhanced antibody-dependent cellular cytotoxicity (ADCC) effector function, targeting CD19-membrane receptor which is highly expressed on malignant chronic lymphocytic leukemia (CLL) cells.

Chronic Lymphocytic Leukemia; Rheumatoid Arthritis

Chronic Lymphocytic Leukemia; Rheumatoid Arthritis