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Creative Biolabs - ADCC+ Antibody

Anti-Cadherin-17 Antibody, Non-Fucosylated (CDH17_A4) (CAT#: BioBet-695ZP) Datasheet

Target
Cadherin-17
Isotype
IgG
Description
Anti-Cadherin-17 Antibody, Non-Fucosylated (BioBet-695ZP) is a humanized monoclonal IgG antibody against Cadherin-17. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Cadherin-17 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CDH17
Full Name
cadherin 17, LI cadherin (liver-intestine)
Background
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants.
Alternative Names
CDH17; cadherin 17, LI cadherin (liver-intestine); HPT1; CDH16; HPT-1; cadherin 17; cadherin-1
Gene ID
1015
UniProt ID
Q12864
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with CDH17 include Metanephric Adenoma and Elsahy-Waters Syndrome.
Related Pathways
Its related pathways are Gastric cancer and ERK Signaling.
Function
Cadherin is a calcium-dependent cell adhesion protein. When connecting cells, they preferentially interact with themselves in an affinity manner; cadherin may therefore help the classification of heterogeneous cell types. LI-cadherin may play a role in the morphological organization of liver and intestine. Participate in intestinal peptide transport.
Post-translational modifications
1.Glycosylation at Asn149, Asn184, Asn250, Asn419, Asn456, Asn546, Asn587, and Asn722 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
CDH17_A4
Host
Humanized
Species Reactivity
Human
Description
The antibody specifically bind to Cadherin-17 with high affinity can be used for treating various cancers, including colorectal cancer.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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