Book a Meeting
Creative Biolabs - ADCC+ Antibody

Anti-Cadherin-11 Antibody, Non-Fucosylated (BioBet-694ZP) (CAT#: BioBet-694ZP) Datasheet

Target
Cadherin-11
Isotype
IgG
Description
Anti-Cadherin-11 Antibody, Non-Fucosylated (BioBet-694ZP) is a humanized monoclonal IgG antibody against Cadherin-11. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Rheumatoid Arthritis
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Cadherin-11 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CDH11
Full Name
cadherin 11, type 2, OB-cadherin (osteoblast)
Background
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.
Alternative Names
CDH11; cadherin 11, type 2, OB-cadherin (osteoblast); OB; CAD11; CDHOB; OSF-4; cadherin 11; cadherin-1; SDP051, HIMI
Gene ID
1009
UniProt ID
P55287
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with CDH11 include Elsahy-Waters Syndrome and Aneurysmal Bone Cysts.
Related Pathways
Its related pathways are ERK Signaling and Cell junction organization.
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Post-translational modifications
1.Glycosylation at Asn455 and Asn540 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-694ZP
Host
Humanized
Species Reactivity
Human
Description
This is a humanized monoclonal antibody to Cadherin-11, which acts as an "adhesive" between cells. Changes in Cad-11 interactions can induce cells to produce proteins that influence the cellular environment. Results from the Phase 1 trial show that SDP051 is safe and well-tolerated at doses up to 10 mg/kg per day with no evidence of significant side effects.
Antibody Indication
Rheumatoid Arthritis

Rheumatoid Arthritis

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
USA

UK

Germany

ISO 9001 Certified - Creative Biolabs Quality Management System.