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Non-Fucosylated Anti-Human B7-H4 (Ab-A (Derived from 20502)) Therapeutic Antibody (CAT#: BioBet-1704ZP) Datasheet

Target
B7-H4
Isotype
IgG
Description
Non-Fucosylated Anti-Human B7-H4 (Ab-A (Derived from 20502)) is a glycosylation-modified therapeutic biobetter antibody.
Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced B7-H4 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
VTCN1
Full Name
V-set domain containing T cell activation inhibitor 1
Background
This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative Names
VTCN1; V-set domain containing T cell activation inhibitor 1; B7X; B7H4; B7S1; B7-H4; B7h. 5; VCTN1; PRO129
Gene ID
79679
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
Ab-A (Derived from 20502)
Host
Murine
Species Reactivity
Human
Description
Afucosylated B7-H4 antibody (Ab-A) has a 140-fold higher affinity for Fcγ receptor IIIA (V158) than the same antibody (Ab-F) with fucosylated Fc.
Indication
Cancer

Related Products

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Non-Fucosylated Anti-Human B7-H4 (2E11) Therapeutic Antibody (CAT#: BioBet-1430ZP)
Non-Fucosylated Anti-Human B7-H4 (2D1) Therapeutic Antibody (CAT#: BioBet-1429ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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