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Anti-IL13 Recombinant Immunotoxin DTAT13 (DT390-IL-13-ATF) (CAT#: BioBet-IT121Z) Datasheet

Target
IL13
IT Type
Ligand-based IT
Description
DTAT13 is a novel recombinant bispecific immunotoxin (IT) composed of truncated diphtheria toxin, urokinase-type plasminogen activator (uPa) amino terminal (AT) fragment and human IL-13 fragment to target receptor glioblastoma (GBM).
Indication
Glioblastoma
Classification
Immuntoxin; biobetter
Construction
DT390-IL-13-ATF

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL13
Full Name
Interleukin 13
Background
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
Alternative Names
Interleukin 13
Gene ID
Entrez Gene: 3596
UniProt ID
UniProtKB: P35225
Species Reactivity
Human
Antibody Indication
Glioblastoma
LIgand
IL13
Toxic Moiety
DT390
Organism
Corynebacterium
Family
Diphtheria toxin
Molecular Mass
35.64kD
Toxic MOA
Diphtheria toxin (DT) is one of the most extensively studied bacterial toxins with intracellular action. The first 390 amino acid residues of DT (DT390) contain the catalytic domain or A chain of DT that inhibits protein synthesis by ADP ribosylation of elongation factor 2 (EF-2) and the translocation domain that translocates the catalytic domain to the cytosol by interaction with cytosolic Hsp90 and thioredoxin reductase.

Glioblastoma

Related Products

Anti-IL13 Recombinant Immunotoxin DTIL13 (DT390-IL13) (CAT#: BioBet-IT120Z)
Anti-IL13 Recombinant Immunotoxin Cintredekin Besudotox (IL13-PE38QQR) (CAT#: BioBet-IT001Z)

All products and services are for Research Use Only. Do Not use in humans.

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