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Anti-HLA-A2-gp100 Recombinant Immunotoxin (G2D12(Fab)-PE38KDEL) (CAT#: BioBet-IT116Z) Datasheet

Target
HLA-A2-gp100
IT Type
Antibody-based IT
Description
The recombinant immunotoxin comprises a 38 kDa truncated variant of Pseudomonas exotoxin A, attached to a Fab fragment of an antibody.
Indication
Melanoma
Classification
Immuntoxin; biobetter
Construction
G2D12(Fab)-PE38KDEL

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
HLA-A2-gp100
Full Name
HLA-A2-gp100
Alternative Names
HLA-A2-gp100
Antibody Clone
G2D12
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Type
Fab
Host
Mouse
Species Reactivity
Human
Antibody Indication
Melanoma
Toxic Moiety
PE38
Organism
Pseudomonas aeruginosa exotoxin A
Family
Pseudomonas exotoxin A
Molecular Mass
38 kDa
Toxic MOA
PE38 is a 38 kDa truncated form of Pseudomonas exotoxin (PE) containing amino acids 253–364 and 381–613. Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa. Vibrio cholerae produces a similar protein called Cholix toxin (Q5EK40). It inhibits elongation factor 2. This is achieved by ADP ribosylation of EF2 using NAD +. This then causes the extension of the polypeptide to stop. This mechanism is similar to diphtheria toxin.

The antibody portion mediated selective binding to target cells, while the toxin portion mediated translocation into the cytosol and subsequent cell killing.

Melanoma

Related Products

Anti-HLA-A2-gp100 Recombinant Immunotoxin (2F1(Fab)-PE38KDEL) (CAT#: BioBet-IT115Z)
Anti-HLA-A2-gp100 Recombinant Immunotoxin (G1(scFv)-PE38) (CAT#: BioBet-IT117Z)

All products and services are for Research Use Only. Do Not use in humans.

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