Anti-CD40L Antibody, Highly Galactosylated (BioBet-GA-151ZP) (CAT#: BioBet-GA-151ZP) Datasheet

CD40LG

CD40 Ligand

CD40LG (CD40 Ligand) is a Protein Coding gene.
Diseases associated with CD40LG include Immunodeficiency With Hyper-Igm, Type 1 and Cd40 Ligand Deficiency.
Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system.
Gene Ontology (GO) annotations related to this gene include cytokine activity and CD40 receptor binding.

Ruplizumab;antova;220651-94-5;Biogen Anti-CD40L;BG9588;hu5c8;CD40LG;CD40 ligand;HIGM1, IMD3, TNFSF5, tumor necrosis factor (ligand) superfamily, member 5 (hyper IgM syndrome);CD40 antigen ligand;CD40L;CD154;gp39;hCD40L;hyper IgM syndrome;T B cell activati

Plasma membrane, Extracellular region or secreted

Its related pathways are NF-KappaB Family Pathway and PEDF Induced Signaling.

Cytokines as ligands for CD40/TNFRSF5 (PubMed:1280226, PubMed:31331973). Co-stimulates the proliferation of T cells and the production of cytokines (PubMed: 8617933). Its cross-linking on T cells produces a co-stimulatory signal, which enhances the production of IL4 and IL10 through TCR/CD3 ligation and CD28 co-stimulation (PubMed: 8617933). Induce the activation of nf-kpa-b (PubMed: 15067037, PubMed: 31331973). Induces the activation of T cell kinases MAPK8 and PAK2 (PubMed: 15067037). Induces tyrosine phosphorylation of CD28 subtype 3 (PubMed: 15067037). Mediates b-cell proliferation in the absence of co-stimulation and mediates IgE production in the presence of IL4 (similar). Participate in the conversion of immunoglobulins (similarity).

Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody

The soluble form derives from the membrane form by proteolytic processing. N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40. Not O-glycosylated.

Protein Based Therapies
Monoclonal antibody (mAb)

Therapeutic Antibody

BioBet-GA-151ZP

Humanized

Human

Recombinant monoclonal antibody to Human CD40L. Ruplizumab (trade name Antova) is a humanized monoclonal antibody intended for the treatment of rheumatic diseases like systemic lupus erythematosus and lupus nephritis. A study showed that the drug was associated with life-threatening thromboembolisms, while another study only found thrombocytopenia.

Allograft rejection

Allograft rejection