Highly Galactosylated Anti-VEGF (Bevacizumab) Antibody (CAT#: BioBet-GA-483ZP) Datasheet

VEGFA

Vascular Endothelial Growth Factor A

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]

Bevacizumab;bevacizumab;216974-75-3;DB00112VEGFA;vascular endothelial growth factor A;vascular endothelial growth factor , VEGF;VEGF A;VPF;vascular permeability factor;VEGF;MVCD1;MGC70609;

Extracellular region or secreted

Its related pathways are HIF1Alpha Pathway and Cell adhesion_Plasmin signaling.

The activity of growth factors in angiogenesis, angiogenesis and endothelial cell growth. Induce endothelial cell proliferation, promote cell migration, inhibit cell apoptosis, and induce vascular permeability. It binds to FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparin sulfate and heparin. NRP1/Neuropilin-1 binds to subtypes of VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR, but does not activate downstream signaling pathways, does not activate angiogenesis, and inhibit tumor growth. Binding to the NRP1 receptor initiates the signaling pathways required for motor neuron axon guidance and cell body migration, including the migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (similar).

Cancer antibody; Cell Biology and Cellular Response antibody; Metabolism antibody; Signaling Transduction antibody

1.Glycosylation at Asn101 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

Bevacizumab

Human

Human

The Highly Galactosylated Anti-VEGF (Bevacizumab), a biobetter antibody contains with a high level of galactosylation.

Colorectal cancers, metastatic

Colorectal cancers, metastatic