Highly Galactosylated Anti-SELL (Aselizumab) Antibody (CAT#: BioBet-GA-439ZP) Datasheet

SELL

Selectin L

This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

Aselizumab; 395639-53-9; HuDreg-55; HuEP5C7; SMART Anti-L Selectin; SELL; selectin L; LNHR, LYAM1, lymphocyte adhesion molecule 1; L-selectin; CD62L; hLHRc; LAM 1; LAM1; Leu 8; LSEL; Lyam 1; PLNHR; gp90-MEL; pln homing receptor; lymph node homing receptor

Plasma membrane

Its related pathways are Cell surface interactions at the vascular wall and Hematopoietic Stem Cells and Lineage-specific Markers.

Calcium-dependent lectin mediates cell adhesion by binding to glycoproteins on neighboring cells. It mediates the adhesion of lymphocytes to the endothelial cells of the surrounding lymph node high endothelial venules. Promote the initial aggregation and rolling of white blood cells in the endothelium.

1.N-glycosylated 2.Glycosylation at Asn60, Asn104, Asn177, Asn232, Asn246, and Asn271 3.Ubiquitination at Lys78, Lys93, Lys134, Lys137, and Lys141 4.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG4

Aselizumab

Humanized

Human

The Highly Galactosylated Anti-SELL (Aselizumab), a biobetter antibody contains with a high level of galactosylation.

Unknown

Unknown