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Creative Biolabs - ADCC+ Antibody

Anti-selectin P Antibody, Highly Galactosylated (BioBet-GA-440ZP) (CAT#: BioBet-GA-440ZP) Datasheet

Target
selectin P
Isotype
IgG4, κ
Description
Anti-selectin P Antibody, Highly Galactosylated (BioBet-GA-440ZP) is a human IgG4, κ antibody against selectin P which contains with a high level of galactosylation.
Antibody Indication
Myocardial infection
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced selectin P antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
SELP
Full Name
Selectin P
Background
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]
Alternative Names
Inclacumab;1256258-86-2;RG1512;R1512;RO4905417;LC1004-002;SELP;selectin P (granule membrane protein 140kDa, antigen CD62);GRMP, selectin P (granule membrane protein 140kD, antigen CD62);P-selectin;CD62;CD62P;GMP140;PADGEM;PSEL;GMP-140;granule membrane pro
Gene ID
6403
UniProt ID
P16109
Cellular Localization
Plasma membrane
Genecards
10721
Involvement in Disease
Its related pathways are amb2 Integrin signaling and Cell surface interactions at the vascular wall. G
Related Pathways
Calcium (2+) receptor-dependent myeloid cells bind to neutrophils and monocytes on carbohydrates. Mediates the interaction of activated endothelial cells or platelets with white blood cells. The recognized ligand is sialic acid-Lewis X. The interaction with SELPLG mediates the rapid rolling of leukocytes on the surface of blood vessels at the initial stage of inflammation.
Function
Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody
Field of research
1.Glycosylation at Asn54, Asn98, Asn180, Asn212, Asn219, Asn272, Asn411, Asn460, Asn518, Asn665, Asn716, Asn723, and Asn741 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG4, κ
Antibody Clone
BioBet-GA-440ZP
Host
Human
Species Reactivity
Human
Description
The Highly Galactosylated Anti-selectin P (Inclacumab), a biobetter antibody contains with a high level of galactosylation.
Antibody Indication
Myocardial infection

Myocardial infection

Related Products

Anti-Selectin P Antibody, Recycling (AES-0622-ZP79) (CAT#: AES-0622-ZP79)
Anti-Selectin P Antibody, On-Target (AES-0622-ZP735) (CAT#: AES-0622-ZP735)
Anti-Selectin P Antibody, FcγRIIB Binding Enhanced (AES-0622-ZP407) (CAT#: AES-0622-ZP407)
Anti-Selectin P Antibody, Half-Life Extended (AES-0622-ZP1063) (CAT#: AES-0622-ZP1063)
Anti-selectin P Antibody, Non-Fucosylated (BioBet-440ZP) (CAT#: BioBet-440ZP)

All products and services are for Research Use Only. Do Not use in humans.

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