Anti-Integrin alpha 5 beta 1 Antibody, Highly Galactosylated (BioBet-GA-328ZP) (CAT#: BioBet-GA-328ZP) Datasheet

ITGA5

Integrin Subunit Alpha 5

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

Volociximab;558480-40-3;M200;ITGA5;integrin, alpha 5 (fibronectin receptor, alpha polypeptide);FNRA;integrin alpha-5;CD49e;VLA-5;integrin alpha-F;CD49 antigen-like family member E;fibronectin receptor subunit alpha;fibronectin receptor, alpha subunit;very

Membrane

Its related pathways are Integrin Pathway and Degradation of the extracellular matrix.

1.Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the R-G-D sequence in the ligand. ITGA5: ITGB1 binds to PLA2G2A through a site (site 2) different from the classical ligand binding site (site 1), thereby inducing a change in the conformation of the integrin and enhancing the binding of the ligand to site 1. ITGA5: ITGB1 acts as a receptor for fibrillin 1 (FBN1) and mediates r-g-d-dependent cell adhesion to FBN1. ITGA5: ITGB1 is a receptor for IL1B, and its binding is essential for IL1B signaling. ITGA5: ITGB3 is the receptor for soluble CD40LG and is required for CD40/CD40LG signal transduction. 2.(Microbial infection) Integrin ITGA5: ITGB1 acts as a receptor for human metapneumovirus. 3.(Microbial infection) Integrin ITGA2: ITGB1 acts as a receptor for human parvovirus B19. 4.(Microbial infection) In the case of HIV-1 infection, the interaction with the extracellular virus Tat protein seems to enhance the angiogenesis of Kaposi's sarcoma lesions.

Proteolytic cleavage by PCSK5 mediates activation of the precursor.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG4

BioBet-GA-328ZP

Chimeric

Human

Recombinant monoclonal antibody to Integrin Integrin alpha 5 beta 1. Volociximab (also known as M200) is a chimeric monoclonal antibody jointly for treatment of a variety of advanced solid tumors. It binds to and inhibits the functional activity of α5β1 integrin.
It is thought to reduce metastases. Early results show potential in renal cell cancers.

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