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Highly Galactosylated Anti-HER2 (Pertuzumab) Antibody (CAT#: BioBet-GA-007ZP) Datasheet

The Highly Galactosylated Anti-HER2 (Pertuzumab), a biobetter antibody contains with a high level of galactosylation.
Early Breast Cancer
Inflammatory carcinoma of the breast
Locally Advanced Breast Cancer (LABC)
Metastatic Breast Cancer
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced HER2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
Full Name
erb-b2 receptor tyrosine kinase 2
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Alternative Names
NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
Gene ID
UniProt ID
Cellular Localization
Plasma membrane, Endosome, Nucleus.
Involvement in Disease
Its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and RET signaling.
Related Pathways
1.Protein tyrosine kinases are part of several cell surface receptor complexes, but obviously require a co-receptor to which a ligand binds. An essential component of the neurotonin receptor complex, although neurotonin does not interact with it alone. GP30 is a potential ligand for this receptor. Regulate the growth and stability of peripheral microtubules (MTs). After ERBB2 is activated, the memo1-rhoa-991 signaling pathway triggers the phosphorylation of GSK3B on the cell membrane, thereby inhibiting GSK3B. This prevents the phosphorylation of APC and CLASP2, allowing them to bind to the cell membrane. In turn, membrane-bound APC allows MACF1 to localize to the cell membrane, which is necessary for microtubule capture and stabilization. 2.Participate in transcriptional regulation in the nucleus. It is associated with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Participate in CDKN1A transcriptional activation; functions include STAT3 and SRC. Participate in the transcription of rRNA genes through RNA Pol I, and promote protein synthesis and cell growth.
Cancer antibody; Controls and Markers antibody; Signaling Transduction antibody; Circulating Tumor Cells BioMarker antibody
Field of research
Autophosphorylated. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable). Ligand-binding increases phosphorylation on tyrosine residues (PubMed:27134172). Signaling via SEMA4C promotes phosphorylation at Tyr-1248 (PubMed:17554007). Dephosphorylated by PTPN12 (PubMed:27134172).
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
Antibody Clone
Species Reactivity
Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular domain of human epidermal growth factor receptor 2 protein (HER2).
Early Breast Cancer
Inflammatory carcinoma of the breast
Locally Advanced Breast Cancer (LABC)
Metastatic Breast Cancer
2C4 Antibody
Monoclonal Antibody 2C4

Pertuzumab is a humanized monoclonal antibody designed to target the extracellular dimerization domain of Her2. At the same time, it can also inhibit the dimerization of other HER family members (HER1, HER2, HER3 and HER4) on the surface of cancer cells. In addition, Pertuzumab also inhibits downstream activation of the PI3K and MAPK pathways. Like trastuzumab, pertuzumab also stimulates antibody-dependent cell-mediated cytotoxicity (ADCC).

Pertuzumab can be used in combination with trastuzumab and docetaxel to treat patients with HER2-positive metastatic breast cancer who have not received anti-HER2 treatment or chemotherapy for metastatic disease.

All products and services are for Research Use Only. Do Not use in humans.


Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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