Highly Galactosylated Anti-CD20 (Tositumomab) Antibody (CAT#: BioBet-GA-008ZP) Datasheet

MS4A1

membrane spanning 4-domains A1

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.

B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16

Plasma membrane

Its related pathways are Hematopoietic cell lineage and Hematopoietic Stem Cells and Lineage-specific Markers.

b lymphocyte-specific membrane protein, which is involved in the regulation of cellular calcium influx necessary for the development, differentiation and activation of b lymphocytes (PubMed:3925015, PubMed:7684739, PubMed:12920111). After activation of b-cell receptor/BCR, it acts as a component of stored and operated calcium (SOC) channels to promote calcium influx (PubMed:7684739, PubMed:12920111, PubMed:18474602).

Cancer antibody; Developmental Biology antibody; Immune System antibody; B cell Marker antibody; Immature B Cell Marker antibody; Inflammatory Cell Marker antibody; Tumor-infiltrating Lymphocyte Study antibody

Phosphorylated. Might be functionally regulated by protein kinase(s).

Protein Based Therapies
Monoclonal antibody (mAb)

IgG2a

Tositumomab

Mouse

Human

Tositumomab is a murine IgG2aλ monoclonal antibody against the CD20 antigen, produced in mammalian cells. Tositumomab is used in combination with the radioisotope iodine 131, a drug combination known as Bexxar. Tositumomab was developed by Corixa and approved in 2003 for a personalized protocol to treat relapsed and refractory non-Hodgkin's lymphoma.

Chronic Lymphocytic Leukaemia (CLL)
Chronic Lymphocytic Leukemia (CLL) - Refractory

Not Available

Tositumomab specifically binds the CD20 antigen found on mature B lymphocytes. CD20 molecules are expressed on normal B lymphocytes (from B to mature B lymphocytes) and B cell CLL. Studies have shown that possible mechanisms of cell lysis include complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity.

For treatment of non-Hodgkin's lymphoma (CD20 positive, follicular)

Chronic Lymphocytic Leukaemia (CLL)
Chronic Lymphocytic Leukemia (CLL) - Refractory