Target

GPNMB

IT Type

Antibody-based IT

Description

The recombinant anti-GPNMB immunotoxin comprises a disulfide-linked Fv (VH/VL) anti-GPNMB antibody fragment recombinantly connected to a 38 kD cytotoxic truncation of Pseudomonas exotoxin A ("PE", the 38 kD truncation is known in the art as "PE38"). PE38 is created by deleting from the 613 amino acid residue sequence of native PE residues 1-252, which correspond to domain I, along with residues 365-380 of domain Ib.

Indication

Lung cancer; Breast cancer

Classification

Immuntoxin; biobetter

Construction

B307(scFv)-PE38

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.

Official Name

GPNMB

Full Name

Glycoprotein Nmb

Background

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GPNMB (Glycoprotein Nmb) is a Protein Coding gene.
Diseases associated with GPNMB include Melanoma and Glioblastoma Multiforme.
Among its related pathways are Signaling by GPCR and Signaling by PTK6.
Gene Ontology (GO) annotations related to this gene include heparin binding and integrin binding.
An important paralog of this gene is PMEL.
Could be a melanogenic enzyme.

Alternative Names

Glycoprotein Nmb; Hematopoietic Growth Factor Inducible Neurokinin-1; Glycoprotein Nonmetastatic Melanoma Protein B; Glycoprotein (Transmembrane) Nmb; Transmembrane Glycoprotein HGFIN; Glycoprotein Nmb-Like Protein; Glycoprotein NMB;

Gene ID

Entrez Gene: 10457

UniProt ID

UniProtKB: Q14956

Antibody Clone

B307

Biologic Classification

Protein Based Therapies
Monoclonal antibody (mAb)

Antibody Type

scFv

Host

Mouse

Species Reactivity

Human

Antibody Indication

Lung cancer; Breast cancer

Toxic Moiety

PE38

Organism

Pseudomonas aeruginosa exotoxin A

Family

Pseudomonas exotoxin A

Molecular Mass

38 kDa

Toxic MOA

PE38 is a 38 kDa truncated form of Pseudomonas exotoxin (PE) containing amino acids 253–364 and 381–613. Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa. Vibrio cholerae produces a similar protein called Cholix toxin (Q5EK40). It inhibits elongation factor 2. This is achieved by ADP ribosylation of EF2 using NAD +. This then causes the extension of the polypeptide to stop. This mechanism is similar to diphtheria toxin.

The antibody portion mediated selective binding to target cells, while the toxin portion mediated translocation into the cytosol and subsequent cell killing.

Lung cancer; Breast cancer

Anti-GPNMB Recombinant Immunotoxin (B307(scFv)-PE38) (CAT#: BioBet-IT101Z) Datasheet

Biobetters

Target

Target Moiety

Toxin Moiety

Mechanism of Action

Indication

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