IT Type
Antibody-based IT
Description
The recombinant anti-GPC3 immunotoxin comprises a human sdAb (HN3) fragment recombinantly connected to a a wild‐type Pseudomonas exotoxin PE domain. The treatment of human sdAb (HN3) immunotoxin targeting Glypican-3 (GPC3) can lead to effective tumor regression by blocking protein synthesis and down-regulating the Wnt signaling pathway.
Indication
Liver cancer
Classification
Immuntoxin; biobetter
Construction
HN3‐mPE24
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
GPC3
Full Name
Glypican 3
Background
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Alternative Names
Glypican 3; Intestinal Protein OCI-5; Glypican Proteoglycan 3; GTR2-2; MXR7; Heparan Sulphate Proteoglycan; Secreted Glypican-3; Glypican-3;
Gene ID
Entrez Gene: 2719
UniProt ID
UniProtKB: P51654
Antibody Clone
HN3
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Type
sdAb
Antibody Indication
Liver cancer
Toxic Moiety
PE24
Organism
Pseudomonas aeruginosa exotoxin A
Family
Pseudomonas exotoxin A
Molecular Mass
24 kDa
Toxic MOA
PE24 is a 24 kDa fragment of Pseudomonas exotoxin A. It specifically targets and kills cancer cells, and then endocytosis occurs. After proteolytic degradation, the PE28 fragment catalyzes ADP ribosylation and EF2 inactivation when introduced into the cytoplasmic sol, resulting in inhibition of protein synthesis and cell death.
The antibody portion mediated selective binding to target cells, while the toxin portion mediated translocation into the cytosol and subsequent cell killing.
