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Fc Engineered Anti-Human PCSK9 Antibody, CDC-Enhanced (Biobet-C407ZP) (CAT#: Biobet-C407ZP) Datasheet

Target
PCSK9
Isotype
Human IgG2, λ
Description
CDC-Enhanced Evolocumab is a Fc-modified anti-PCSK9 therapeutic biobetter antibody. Creative Biolabs' advanced CDC-enhanced antibody platform allows for the production of Fc engineered therapeutic CDC⁺ antibodies. By mutating key amino acids of the Fc region of Evolocumab, Evolocumab exhibits a greater binding capacity to C1q, thereby achieving enhanced CDC activity.
Indication
Atherosclerosis
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced rituximab. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
PCSK9
Full Name
Proprotein Convertase Subtilisin/Kexin Type 9
Background
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene ID
353175
UniProt ID
Q8NBP7
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
Human IgG2, λ
Indication
Atherosclerosis

Atherosclerosis

Related Products

Fc Engineered Anti-Human PCSK9 Antibody, CDC-Enhanced (Biobet-C405ZP) (CAT#: Biobet-C405ZP)
Fc Engineered Anti-Human PCSK9 Antibody, CDC-Enhanced (Biobet-C406ZP) (CAT#: Biobet-C406ZP)
Fc Engineered Anti-Human PCSK9 Antibody, CDC-Enhanced (Biobet-C408ZP) (CAT#: Biobet-C408ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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