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Fc Engineered Anti-Human IL23 Therapeutic Antibody, a CDC-Enhanced Biobetter [Lot: CB20-PZ299] (CAT#: Biobet-C299ZP) Datasheet

Target
IL23
Isotype
Human Therapeutic Antibody
Description
CDC-Enhanced Tildrakizumab is a Fc-modified anti-IL23 therapeutic biobetter antibody. Creative Biolabs' advanced CDC-enhanced antibody platform allows for the production of Fc engineered therapeutic CDC⁺ antibodies. By mutating key amino acids of the Fc region of Tildrakizumab, Tildrakizumab exhibits a greater binding capacity to C1q, thereby achieving enhanced CDC activity.
Indication
Psoriasis
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced rituximab. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL23A
Full Name
Interleukin 23 Subunit Alpha
Background
This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
Alternative Names
Tildrakizumab;1326244-10-3;MK-3222;SCH 900222;IL23A;interleukin 23, alpha subunit p19;interleukin-23 subunit alpha;IL 23;IL 23A;IL23P19;interleukin six;G CSF related factor;P19;SGRF;IL-23-A;IL-23p19;IL-23 subunit alpha;interleukin 23 p19 subunit;interleuk
Gene ID
51561
UniProt ID
Q9NPF7
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
Human Therapeutic Antibody
Description
Recombinant humanized (from mouse) antibody expressed in CHO binding to human IL23. Tildrakizumab is a monoclonal antibody designed for the treatment of immunologically mediated inflammatory disorders.
Indication
Psoriasis

Psoriasis

Related Products

Fc Engineered Anti-Human IL23 Therapeutic Antibody, a CDC-Enhanced Biobetter [Lot: CB20-PZ14] (CAT#: BioBet-C014ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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