Fc Engineered Anti-Human HER2 Therapeutic Antibody, a CDC-Enhanced Biobetter [Lot: CB20-PZ07] (CAT#: BioBet-C007ZP) Datasheet

ERBB2

erb-b2 receptor tyrosine kinase 2

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Protein Based Therapies
Monoclonal antibody (mAb)

Whole Humanized Antibody

Early Breast Cancer
Inflammatory carcinoma of the breast
Locally Advanced Breast Cancer (LABC)
Metastatic Breast Cancer

Pertuzumab can be used in combination with trastuzumab and docetaxel to treat patients with HER2-positive metastatic breast cancer who have not received anti-HER2 treatment or chemotherapy for metastatic disease.