Fc Engineered Anti-Human GD2 Therapeutic Antibody, a CDC-Enhanced Biobetter [Lot: CB20-PZ242] (CAT#: Biobet-C242ZP) Datasheet

Target
GD2
Isotype
Human IgG1, κ
Description
CDC-Enhanced Dinutuximab is a Fc-modified anti-GD2 therapeutic biobetter antibody. Creative Biolabs' advanced CDC-enhanced antibody platform allows for the production of Fc engineered therapeutic CDC⁺ antibodies. By mutating key amino acids of the Fc region of Dinutuximab, Dinutuximab exhibits a greater binding capacity to C1q, thereby achieving enhanced CDC activity.
Indication
Neuroblastoma
Classification
Therapeutic antibody; biobetter
Patent
Not Available
Status
Preclinical

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced rituximab. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
GD2
Alternative Names
Dinutuximab; Unituxin; Ch14.18; APN311; Disialoganglioside GD2; Ganglioside G2; GD2
Trade name
Dinutuximab
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
Human IgG1, κ
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant chimeric (human/Mouse) antibody expressed in CHO binding to human GD2. Dinutuximab is a chimeric monoclonal antibody that induces antibody dependent cell-mediated cytotoxicity. Dinutuximab is intended as maintenance therapy (targeting minimal residual disease) for high risk neuroblastoma, administered after induction therapy, autologous stem cell transplantation and/or radiotherapy.
Indication
Neuroblastoma

Neuroblastoma

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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USA

UK