Isotype
Whole Chimeric Antibody
Description
CDC-enhanced Dinutuximab is a Fc-modified anti-GD2 therapeutic biobetter. Creative Biolabs' advanced CDC-enhanced antibody platform allows for the production of Fc engineered therapeutic CDC⁺ antibodies. By mutating key amino acids of the Fc region of Dinutuximab, the Fc region of Dinutuximab exhibits a greater binding capacity to C1q, thereby achieving enhanced CDC activity.
Indication
Severe Eosinophilic Asthma
Severe nasal polyposis
Adult patients with eosinophilic granulomatosis
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Dinutuximab. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
Chimeric IgG1
Description
Dinutuximab is a chimeric monoclonal antibody composed of mouse and human components used as a second-line treatment for children with high-risk neuroblastoma. It targets the glycolipid GD2 expressed on neuroblastoma cells and normal cells of neuroectodermal origin, including the central nervous system and peripheral nerves. Dinutuximab obtained marketing authorization in the U.S. and Europe in 2015.
Indication
High Risk Neuroblastoma
Melanoma
Synonyms
Dinutuximab beta
Monoclonal antibody ch14.18
Ch14.18
