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Fc Engineered Anti-Human EGFR Therapeutic Antibody, a CDC-Enhanced Biobetter [Lot: CB20-PZ09] (CAT#: BioBet-C009ZP) Datasheet

Target
EGFR
Isotype
Human Antibody
Description
CDC-enhanced Necitumumab is a Fc-modified anti-EGFR therapeutic biobetter. Creative Biolabs' advanced CDC-enhanced antibody platform allows for the production of Fc engineered therapeutic CDC⁺ antibodies. By mutating key amino acids of the Fc region of Necitumumab, the Fc region of Necitumumab exhibits a greater binding capacity to C1q, thereby achieving enhanced CDC activity.
Indication
Metastatic Colorectal Cancer (MCRC)
Metastatic Squamous Cell Carcinoma of the Head and Neck
Advanced squamous cell carcinoma of the head and neck
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Necitumumab. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
EGFR
Full Name
epidermal growth factor receptor
Background
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.
Gene ID
1956
UniProt ID
P00533
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
Human IgG1
Indication
Metastatic Non-Small Cell Lung Cancer

Necitumumab is approved as a first-line treatment for metastatic squamous non-small cell lung cancer (NSCLC) with cisplatin and gemcitabine.
Solide Tumors
Metastatic Non-Small Cell Lung Cancer

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All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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