IT Type
Antibody-based IT
Description
The immunotoxin is comprised of a single-chain fragments of anti-human CD86 monoclonal antibody IG10H6D10, coupled to a gelonin toxin wherein the binding of the immunotoxin to CD86 results in the killing of the CD86 expressing cell.
Indication
Bladder cancer; myeloma
Classification
Immuntoxin; biobetter
Construction
1G10H6D10(svFv)-Gelonin
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD86
Full Name
CD86 Molecule
Background
CD86 (CD86 Molecule) is a Protein Coding gene.
Diseases associated with CD86 include Gallbladder Squamous Cell Carcinoma and Myocarditis.
Among its related pathways are Cytokine Signaling in Immune system and Th2 Differentiation Pathway.
Gene Ontology (GO) annotations related to this gene include receptor binding and coreceptor activity.
An important paralog of this gene is CD80.
Alternative Names
CD86 Molecule; CD86 Antigen (CD28 Antigen Ligand 2, B7-2 Antigen); CTLA-4 Counter-Receptor B7.2; CD28LG2; FUN-1; BU63; B70; B-Lymphocyte Activation Antigen B7-2;
Gene ID
Entrez Gene: 942
UniProt ID
UniProtKB: P42081
Antibody Clone
1G10H6D10
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Type
scFv
Antibody Indication
Bladder cancer; myeloma
Toxic Moiety
Gelonin
Organism
Gelonium multiflorum
Family
Protein toxin
Molecular Mass
30 kDa
Toxic MOA
Gelonin is called "ribosomal inactivation protein" and has been concerned by many researchers as a potential cancer treatment method. Gelonin is a protein toxin of approximately 30 kDa found in the seeds of the Himalayan plant Polygonum multiflorum. In a cell-free system, gelonin exerts a powerful N-glycosidase activity on the 28S rRNA unit of the eukaryotic ribosome by cleaving adenine at 4324. Gelonin lacks a carbohydrate binding domain, which exists in the form of β-chains, and therefore cannot pass through the plasma membrane, so it is very effective in cell-free systems.
The antibody portion mediated selective binding to target cells, while the toxin portion mediated translocation into the cytosol and subsequent cell killing.
