IT Type
Antibody-based IT
Description
The immunotoxin is comprised of a single-chain fragments of anti-human CD33 monoclonal antibody, coupled to a gelonin toxin wherein the binding of the immunotoxin to CD33 results in the killing of the CD33 expressing cell.
Indication
Acute myelogenous leukemia (AML)
Classification
Immuntoxin; biobetter
Construction
M195-gelonin
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD33
Full Name
CD33 Molecule
Background
CD33 (CD33 Molecule) is a Protein Coding gene.
Diseases associated with CD33 include Gallbladder Lymphoma and Extracutaneous Mastocytoma.
Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System.
Gene Ontology (GO) annotations related to this gene include receptor activity and carbohydrate binding.
An important paralog of this gene is SIGLEC6.
Alternative Names
CD33 Molecule; Sialic Acid-Binding Ig-Like Lectin 3; CD33 Antigen (Gp67); SIGLEC-3; SIGLEC3; Gp67;
Gene ID
Entrez Gene: 945
UniProt ID
UniProtKB: P20138
Antibody Clone
M195
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Type
scFv
Antibody Indication
Acute myelogenous leukemia (AML)
Toxic Moiety
Gelonin
Organism
Gelonium multiflorum
Family
Protein toxin
Molecular Mass
30 kDa
Toxic MOA
Gelonin is called "ribosomal inactivation protein" and has been concerned by many researchers as a potential cancer treatment method. Gelonin is a protein toxin of approximately 30 kDa found in the seeds of the Himalayan plant Polygonum multiflorum. In a cell-free system, gelonin exerts a powerful N-glycosidase activity on the 28S rRNA unit of the eukaryotic ribosome by cleaving adenine at 4324. Gelonin lacks a carbohydrate binding domain, which exists in the form of β-chains, and therefore cannot pass through the plasma membrane, so it is very effective in cell-free systems.
The antibody portion mediated selective binding to target cells, while the toxin portion mediated translocation into the cytosol and subsequent cell killing.
Acute myelogenous leukemia (AML)
