Anti-CD20 Recombinant Immunotoxin MT-3724 (scFv-SLTA) (CAT#: BioBet-IT014Z) Datasheet

Target
CD20
IT Type
Antibody-based IT
Description
MT-3724 is a novel recombinant fusion protein consisting of a CD20 binding variable fragment (scFv) fused to Shiga-like toxin-I A1 (SLTA).
Indication
Refractory B-cell malignancies; B-cell Leukemia/Lymphoma
Classification
Immuntoxin; biobetter
Construction
scFv-SLTA

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
MS4A1
Full Name
membrane spanning 4-domains A1
Background
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.
Alternative Names
B1; S7; Bp35; CD20; CVID5; MS4A2; LEU-16;
Antibody Clone
2F2
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Type
scFv
Host
Mouse
Species Reactivity
Human
Antibody Indication
Refractory B-cell malignancies; B-cell Leukemia/Lymphoma
Toxic Moiety
Shiga-like toxin-A
Organism
Shigella dysenteriae
Family
Shiga-like toxin-A
Toxic MOA
Shiga and Shiga-like toxins (Stxs) are produced by bacteria that can cause infectious diseases. These protein toxins belong to the A-B toxin group. The binding part of Shiga toxin consists of pentamers that recognize specific glycosphingolipids on the cell surface. Most of these toxins bind to fructose ceramide (Gb3). After binding, the toxin is endocytosed and retrogradely transported to the Golgi apparatus and endoplasmic reticulum (ER), where the enzyme activity is partially transferred to the cytosol. After entering the cytoplasm, the toxin deactivates the ribosome by removing an adenine from 28S RNA, thereby inhibiting protein synthesis.

The antibody portion mediated selective binding to target cells, while the toxin portion mediated translocation into the cytosol and subsequent cell killing.

Refractory B-cell malignancies; B-cell Leukemia/Lymphoma

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
  • *
USA

UK