IT Type
Bispecific IT
Description
Patients with refractory and relapsed acute lymphoblastic leukemia (ALL) need new drugs. Combotox is a 1: 1 mixture of two immunotoxins (IT) by coupling the deglycosylated ricin A chain (dgRTA) to monoclonal antibodies against CD22 (RFB4-dgRTA) and CD19 (HD37-dgRTA). Preclinical data indicate that Combotox can effectively kill pre-B-ALL cells and cells from pre-B-ALL patients.
Indication
Refractory B-lineage Acute Lymphoblastic Leukaemia
Classification
Immuntoxin; biobetter
Construction
RFB4(IgG)-dgA; HD37(IgG)-dgA
Synonyms
IgG-HD37-dgA/IgG-RFB4-dgA immunotoxins.
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CD19;CD22
Full Name
CD19 Molecule; CD22 Molecule
Background
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.
Alternative Names
CD19 Molecule; B-Lymphocyte Surface Antigen B4; T-Cell Surface Antigen Leu-12; Differentiation Antigen CD19; CD19 Antigen; B-Lymphocyte Antigen CD19; CVID3; B4; CD22 Molecule; CD22 Antigen; Sialic Acid-Binding Ig-Like Lectin 2; B-Lymphocyte Cell Adhesion Molecule; T-Cell Surface Antigen Leu-14; SIGLEC-2;
Antibody Clone
RFB4; HD37
Antibody Type
IgG
Antibody Indication
Refractory B-lineage Acute Lymphoblastic Leukaemia
Toxic Moiety
Deglycosylated ricin A chain (dgA)
Organism
Ricinus communis (Castor bean)
Family
Ricin
Molecular Mass
30.1 kDa
Toxic MOA
Deglycosylated ricin A chain (dgA) is an N-glycoside hydrolase composed of 267 amino acids. Ricin is a toxalbumin, a biological toxin whose mechanism of action is inhibition of protein synthesis (manufacture of proteins) in eukaryotic cells; cell death results from the absence of proteins.
Refractory B-lineage Acute Lymphoblastic Leukaemia
