IT Type
Antibody-based IT
Description
The recombinant immunotoxin consists of a CD117 monoclonal antibody that in combination with a streptavidin-saporin conjugate.
Indication
Gastrointestinal stromal tumors and melanoma
Classification
Immuntoxin; biobetter
Construction
2B8-SAP
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
KIT
Full Name
KIT proto-oncogene, receptor tyrosine kinase
Background
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative Names
C-Kit, CD117, MASTC, PBT, SCFR
Antibody Clone
2B8
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Type
scFv
Antibody Indication
Gastrointestinal stromal tumors and melanoma
Toxic Moiety
Saporin
Organism
Saponaria officinalis
Family
Plant toxin
Toxic MOA
Saporin, a plant toxin derived from Saponaria officinalis, disrupts protein synthesis by inactivating the 60S portion of the ribosomal complex.
The antibody portion mediated selective binding to target cells, while the toxin portion mediated translocation into the cytosol and subsequent cell killing.
Gastrointestinal stromal tumors and melanoma
