IT Type
Antibody-based IT
Description
CC chemokine receptor 4 (CCR4) is expressed on the surface of certain T cell derived tumors, including adult T cell leukemia-lymphoma, adult peripheral T cell lymphoma, T cell acute lymphoblastic leukemia and CTCL. The DT-antiCCR4 fusion, DT390-scFv, is designed to directly consume human CCR4 + tumor cells and CCR4 + Tregs as a combined cancer treatment. DT390-scFv contains the diphtheria toxin with residue 390 at the N-terminus, followed by the VL and VH domains of the anti-CCR4 antibody.
Indication
Adult T-cell leukemia-lymphoma, adult peripheral T-cell lymphoma, T-cell acute lymphoblastic leukemia, and CTCL
Classification
Immuntoxin; biobetter
Construction
DT390-scFv
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop our ADCC/CDC-enhanced antibodies or immutoxins. For commercial partners interested in our therapeutic biobetter product, Creative Biolabs welcomes collaboration.
Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CCR4
Full Name
C-C Motif Chemokine Receptor 4
Background
CCR4 (C-C Motif Chemokine Receptor 4) is a Protein Coding gene.
Diseases associated with CCR4 include Cutaneous T Cell Lymphoma and Mycosis Fungoides.
Among its related pathways are Akt Signaling and Peptide ligand-binding receptors.
Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity.
An important paralog of this gene is CCR5.
Alternative Names
C-C Motif Chemokine Receptor 4; Chemokine (C-C Motif) Receptor 4; C-C CKR-4; CC-CKR-4; CMKBR4; CCR-4; K5-5; C-C Chemokine Receptor Type 4;
Gene ID
Entrez Gene: 1233
UniProt ID
UniProtKB: P51679
Antibody Clone
1567
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Type
scFv
Antibody Indication
Adult T-cell leukemia-lymphoma, adult peripheral T-cell lymphoma, T-cell acute lymphoblastic leukemia, and CTCL
Toxic Moiety
DT390
Organism
Corynebacterium
Family
Diphtheria toxin
Molecular Mass
35.64 kD
Toxic MOA
Diphtheria toxin (DT) is one of the most extensively studied bacterial toxins with intracellular action. The first 390 amino acid residues of DT (DT390) contain the catalytic domain or A chain of DT that inhibits protein synthesis by ADP ribosylation of elongation factor 2 (EF-2) and the translocation domain that translocates the catalytic domain to the cytosol by interaction with cytosolic Hsp90 and thioredoxin reductase.
The antibody portion mediated selective binding to target cells, while the toxin portion mediated translocation into the cytosol and subsequent cell killing.
Adult T-cell leukemia-lymphoma, adult peripheral T-cell lymphoma, T-cell acute lymphoblastic leukemia, and CTCL
