An archive of ADCC/CDC-enhanced biobetter antibodies developed by Creative Biolabs' state-of-the-art technology platform.
Creative Biolabs has long-term experience in the detection of cell-based monoclonal antibody (mAb) therapeutics. Our scientific research team can provide support for the development, optimization, identification and verification of key bioassays, from simple first-level performance measurement to comprehensive characterization of biological activity of biobetter molecules. We have expertise in measuring the cell growth, cell death, induction of immune effector function, biomarker expression, induction or inhibition of signaling events, and methods for antibody internalization. Our experts work closely with you to provide a fully validated efficacy test to ensure a complete solution for your molecular characterization.
The right partner is essential for the development and operation of cell-based potency and bioassays, as these are considered to be one of the most challenging methods required in the drug development process. In addition to playing a key role in potency determination, in vitro bioassays can also make true physiologically relevant measurements of the biological activity between the mAb, its intended target and Fc effector functions.
Creative Biolabs has spent time solving the well-known variability problem of cell-based bioassay and potency assays to provide a series of innovative technologies and bioassay methods. Our experienced team can provide key technical and regulatory guidance at all stages of biobetter drug development (from discovery to cGMP production) to provide effective and cost-effective total solutions.
Our broad range of cell-based bioassay platform methods ready to customize for your biobetter molecule include:
• Custom Potency Assays
• Antibody-Dependent Cell-mediated Cytotoxicity (ADCC) Assays
• Antibody-dependent Cellular Phagocytosis (ADCP) Assays
• Complement-Dependent Cytotoxicity (CDC) Assays
• Immune Cell Assays
From early candidate selection and product characterization to production, we provide a detection solution through the Mechanism of Action (MOA). Our testing method allows for flexible endpoints (e.g. Fluorescence, Luminescence and Fluorescence Resonance Energy Transfer (FRET)), allowing for a wider assessment of MOA, including:
• Cell Proliferation
• Cytokine release
• Cell signal modulation
• Regulation of inflammatory response (immune cell function and supplement)
• Receptor activation
• Cell Death (apoptosis / necrosis)
• Receptor / ligand binding
• Receptor activation / internalization
• Cell migration & invasion
• Cell adhesion (static and flow dynamic assays)
• Biomarker Expression on protein (intracellular, secreted and surface marker analysis) and on mRNA level
• Immune cell activation and proliferation
• Cytokine quantification
Please browse the product list below to find the right product for you.
|CAT#||Product Name||Assay Type||Product Type||Inquiry|
|CB-P271-AB||Human C5 Protein, Natural - 200 µg||Complement Assay||Protein|
|CB-P272-AB||Human C1q Protein, Natural - 1 mg||Complement Assay||Protein|
|CB-P273-AB||Cobra Venom Factor Protein, Recombinant - 50 µg||Complement Assay||Protein|
|CB-P274-AB||Human Properdin Protein, Natural - 100 µg||Complement Assay||Protein|
|CB-P275-AB||Human Complement factor B Protein, Natural - 250 µg||Complement Assay||Protein|
|CB-P276-AB||Human C4 Protein, Natural - 250 µg||Complement Assay||Protein|
|CB-P277-AB||Rat C5L2 Protein, Peptide - 10 µg||Complement Assay||Protein|
|CB-P278-AB||Human Complement factor I Protein, Natural - 100 µg||Complement Assay||Protein|
|CB-P279-AB||Human Complement factor H Protein, Natural - 250 µg||Complement Assay||Protein|
|CB-P280-AB||Human C3a des Arg Protein, Natural - 50 µg||Complement Assay||Protein|
|CB-P281-AB||Human C3a Protein, Natural - 50 µg||Complement Assay||Protein|
|CB-P282-AB||Human C3 Protein, Natural - 250 µg||Complement Assay||Protein|
|CB-P283-AB||Human C2 Protein, Natural - 50 µg||Complement Assay||Protein|
|CB-P284-AB||Human C1 Protein, Natural - 200 µg||Complement Assay||Protein|
|CB-P285-AB||Human C5L2 Peptide - 10 µg||Complement Assay||Protein|
Biobetter Antibodies Betting on the Future Creative Biolabs Visit
All products and services are for Research Use Only. Do Not use in humans.