CD19

Therapeutic antibodies help improve treatment outcomes for certain disease conditions. However, even with infinite binding affinity for the antigen, conventional antibodies can only bind to the antigen once and lead to an increase in the total plasma antigen concentration in the body. This antibody-mediated antigen accumulation usually occurs because the clearance of antibody-antigen complexes from the circulation is much slower than that of free antigen. This limitation can be overcome by recycling/sweeping antibodies, which actively eliminate circulating soluble antigens. They are pH-responsive antibodies capable of binding the target antigen in a pH-dependent manner.

Creative Biolabs provides recycling antibody engineering services. This allows antibodies to not only bind to target antigens in plasma, but also eliminate or remove them. These engineered antibodies are expected to enhance cellular uptake of antibody-antigen complexes.

Enhanced mouse antigen eliminating

Antibody variable/constant engineering