A recycling antibody combines two antibody engineering techniques: one is variable region engineering, which enables the antibody to bind to the antigen in the plasma and dissociate from the antigen in the endosome (after which the antigen undergoes lysosomal degradation), the other is constant region engineering to increase cellular uptake of antibody-antigen complexes into endosomes.
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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.