Anti-Wilms tumor protein Antibody, Non-Fucosylated (BioBet-1450ZP) (CAT#: BioBet-1450ZP) Datasheet

WT1

Wilms tumor 1

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.

WT1; Wilms tumor 1; GUD; AWT1; WAGR; WT33; NPHS4; WIT-2; EWS-WT1; Wilms tumor protein; amino-terminal domain of EWS|last three zinc fingers of the DNA-binding domain of WT1

Nucleus

Diseases associated with WT1 include Wilms Tumor 1 and Denys-Drash Syndrome.

Its related pathways are Transcriptional misregulation in cancer and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers.

A transcription factor that plays an important role in cell development and survival. Recognize and bind to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of many target genes including EPO. Play an important role in the development of the genitourinary system. It has anticancer and carcinogenic effects in the process of tumor formation. The function may have ectopic specificity: the ectopic type lacking KTS motif may act as a transcription factor. Subtypes containing KTS motifs may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has a low affinity for DNA and can bind RNA.

Cancer antibody; Controls and Markers antibody; Developmental Biology antibody; Gene Regulation antibody

1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1

BioBet-1450ZP

Human

Human

This product is a human IgG1 T-cell receptor mimic monoclonal antibody directed to a 9-amino acid sequence of WT1. This product was used for the treatment of mesothelioma and leukemia.

Cancer

Cancer