Description
Anti-VPAC1 Receptor Antibody, Non-Fucosylated (BioBet-1427ZP) is a humanized monoclonal IgG antibody against VPAC1 Receptor. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Thrombocytopenia
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced VPAC1 Receptor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
VIPR1
Full Name
vasoactive intestinal peptide receptor 1
Background
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene.
Alternative Names
VIPR1; vasoactive intestinal peptide receptor 1; II; HVR1; RDC1; V1RG; VIPR; VIRG; VAPC1; VPAC1; VPAC1R; VIP-R-1; VPCAP1R; PACAP-R2; PACAP-R-2; vasoactive intestinal polypeptide receptor 1; VIP receptor, type I; PACAP type II receptor; VIP and PACAP receptor 1; pituitary adenylate cyclase activating polypeptide receptor, type II
Gene ID
7433
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with VIPR1 include Holoprosencephaly 3 and Hepatitis C.
Related Pathways
Its related pathways are Signaling by GPCR and G alpha (s) signalling events.
Function
This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27> PACAP-38.
Post-translational modifications
1.Glycosylation at Asn58, Asn69, Asn100, and Asn290 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
23A11
Description
The monoclonal antibody to the VPAC1 receptor protein are used for prevention or treatment of thrombocytopenia.
Antibody Indication
Thrombocytopenia
