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Creative Biolabs - ADCC+ Antibody

Anti-Von Willebrand Factor Antibody, Non-Fucosylated (BioBet-487ZP) (CAT#: BioBet-487ZP) Datasheet

Target
Von Willebrand Factor
Isotype
IgG
Description
Anti-Von Willebrand Factor Antibody, Non-Fucosylated (BioBet-487ZP) is a human monoclonal IgG antibody against Von Willebrand Factor. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Acute coronary syndrome (ACS)
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Von Willebrand Factor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
VWF
Full Name
Von Willebrand Factor
Background
This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015]
Alternative Names
Caplacizumab;915810-67-2;ALX-0081;VWF;von Willebrand factor;F8VWF;coagulation factor VIII VWF;VWD;
Gene ID
7450
UniProt ID
P04275
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with VWF include Von Willebrand Disease, Type 1 and Von Willebrand Disease, Type 2.
Related Pathways
Its related pathways are RET signaling and Paradoxical activation of RAF signaling by kinase inactive BRAF.
Function
It is very important in maintaining hemostasis, by forming a molecular bridge between the subendothelial collagen matrix and the platelet surface receptor complex GPIb-IX-V, promoting platelet adhesion to the vascular injury site. It also acts as a partner of coagulation factor VIII, delivering it to the injury site, stabilizing its heterodimer structure and protecting it from premature plasma clearance.
Field of research
Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody
Post-translational modifications
All cysteine residues are involved in intrachain or interchain disulfide bonds. N- and O-glycosylated.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-487ZP
Host
Human
Species Reactivity
Human
Description
ADCC-enhanced (BioBet-487ZP) is a non-fucosylated anti-Von Willebrand Factor therapeutic biobetter antibody.
Antibody Indication
Acute coronary syndrome (ACS)

Acute coronary syndrome (ACS)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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