Anti-Vimentin Antibody, Non-Fucosylated (BioBet-1426ZP) (CAT#: BioBet-1426ZP) Datasheet

VIM

vimentin

This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.

VIM; vimentin; HEL113; CTRCT30; epididymis luminal protein 113

Plasma membrane, Nucleus, Cytoskeleton

Diseases associated with VIM include Cataract 30, Multiple Types and Cataract 30.

Its related pathways are Cytoskeleton remodeling Neurofilaments and Apoptosis and survival Caspase cascade.

Vimantine is a type iii intermediate filament, which exists in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, or outside or at the end. LARP6 is involved in the stabilization of type I collagen mrna of CO1A1 and CO1A2.

Cancer antibody; Controls and Markers antibody; Developmental Biology antibody; Neuroscience antibody; Signaling Transduction antibody; Cancer-associated fibroblast antibody; CAF Marker antibody; EMT Study antibody; Mesenchymal Markers antibody; Fibroblast Marker antibody; Muller Cell Marker antibody; Sarcoma Marker antibody

Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin (By similarity). One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm. Phosphorylated by STK33. O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status. S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1426ZP

Human

Human

The anti-vimentin antibody are used for predicting or diagnosing hypertension and heart disease.

Cancer

Cancer