Description
Anti-TWEAK Receptor Antibody, Non-Fucosylated (BioBet-1379ZP) is a humanized monoclonal IgG antibody against TWEAK Receptor. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced TWEAK Receptor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
TNFRSF12A
Full Name
tumor necrosis factor receptor superfamily, member 12A
Alternative Names
TNFRSF12A; tumor necrosis factor receptor superfamily, member 12A; FN14; CD266; TWEAKR; tumor necrosis factor receptor superfamily member 12A; tweak-receptor; FGF-inducible 14; type I transmembrane protein Fn14; fibroblast growth factor-inducible immediate-early response protein 14
Gene ID
51330
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with TNFRSF12A include Alcoholic Hepatitis and Multiple Sclerosis.
Related Pathways
Its related pathways are Apoptosis Modulation and Signaling and TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions.
Function
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
Field of research
Cancer antibody; Cell Biology and Cellular Response antibody; Signaling Transduction antibody
Post-translational modifications
1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1379ZP
Description
The humanized anti-Fn14 agonistic antibody, BIIB036, as a single agent and in combination with standard of care cancer therapeutics.
Antibody Indication
Cancer
