Target
Tumor necrosis factor receptor TR9
Description
Anti-Tumor necrosis factor receptor TR9 Antibody, Non-Fucosylated (BioBet-1391ZP) is a humanized monoclonal IgG antibody against Tumor necrosis factor receptor TR9. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancers; Autoimmune Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Tumor necrosis factor receptor TR9 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Full Name
tumor necrosis factor receptor superfamily, member 9
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
Alternative Names
TNFRSF9; tumor necrosis factor receptor superfamily, member 9; ILA; 4-1BB; CD137; CDw137; tumor necrosis factor receptor superfamily member 9; CD137 antigen; T cell antigen ILA; T-cell antigen ILA; 4-1BB ligand receptor; homolog of mouse 4-1BB; receptor protein 4-1BB; T-cell antigen 4-1BB homolog; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with TNFRSF9 include Retroperitoneal Hemangiopericytoma and Nodular Goiter.
Related Pathways
Its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and Akt Signaling.
Function
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Post-translational modifications
1.Glycosylation at Asn138 and Asn149 2.Modification sites at PhosphoSitePlus 3.Ubiquitination at Lys219
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Clone
BioBet-1391ZP
Description
The monoclonal antibody to 4-1BB (CD137) T cell molecule may be useful for the treatment of human diseases such as cancers and autoimmune diseases.
Antibody Indication
Cancers; Autoimmune Diseases
